2009 Fiscal Year Final Research Report
Profiling of mRNA expression in intra-hepatic bile duct of biliaryatresia
| Project/Area Number |
20791295
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatric surgery
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| Research Institution | Tohoku University |
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Principal Investigator |
HIDEYUKI Sasaki Tohoku University, 病院, 講師 (40438461)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 胆道閉鎖症 / 肝内胆管 / cDNA microarray |
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| Research Abstract |
In this study, animal model of biliary atresia was established by extrahepatic bile duct ligation, poly I : C intra-peritoneal injection. Liver specimens from these models were applied for cDNA microarray. Interestingly, increasing mRNA expression were detected 1227 genes, including inflammation related gene and apotosis related genes,
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