2009 Fiscal Year Final Research Report
Relationship between prolonged ischemia and rejection in composite tissue allotransplantation
| Project/Area Number |
20791311
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Plastic surgery
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| Research Institution | Oita University |
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Principal Investigator |
SHIMIZU Fumiaki Oita University, 医学部, 助教 (50347027)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 組織培養 / 移植学 |
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| Research Abstract |
Relationship between ischemia time and rejection of transplanted allograft was assessed using Rat composite tissue allo-transplantation model. As the result, clinical observation, histopathological examination and mixed lymphocyte reaction assay revealed that prolonged ischemia increases severity of rejection in skin flap allotransplantation. Higher expression of MHC-II antigen in longer ischemia group might cause these results.
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