2009 Fiscal Year Final Research Report
Decreased death receptor pathway of apoptotic signaling in septic mouse gut : effect of nutrition support
| Project/Area Number |
20791324
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Emergency medicine
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| Research Institution | Kyoto University |
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Principal Investigator |
FUTATSUGI Motonori Kyoto University, 医学研究科, 助教 (70419589)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 敗血症 / 経腸栄養 / Death受容体 |
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| Research Abstract |
In this study, we found that the expression of TNF-R1, Fas, and cleaved caspase-3 was elevated in duodenum or jejunum or ileum in digestive tract of CLP-induced septic mice. In ileum of CLP-induced septic mice with EN, and the expression of death receptors (TNF-R1, Fas) and cleaved caspase-3 was down-regulated.
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