2009 Fiscal Year Final Research Report
The effect of nicaraven to organ dysfunctions in sepsis
| Project/Area Number |
20791326
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Emergency medicine
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| Research Institution | Keio University |
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Principal Investigator |
SUZUKI Takeshi Keio University, 医学部, 助教 (80327600)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 敗血症 / 臓器障害 / 活性酸素種 / ニカラベン |
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| Research Abstract |
I examined the effects of nicaraven to sepsis, using a rat cecal ligation and perforation model. At first, I evaluated whether a nicaraven infusion has beneficial effects to mortality and cardiac dysfunction or not. In the evaluation of cardiac function, I measured cardiac output, cardiac work and cardiac efficiency using a working heart model. Although there are only a few datas, a nicaraven therapy has little beneficial effects to mortality and cardac dysfunction at this time.
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