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2009 Fiscal Year Final Research Report

Mechanism of green tea catechin-induced apoptosis through MAPK signaling pathway in human oral cancer cells

Research Project

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Project/Area Number 20791330
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Morphological basic dentistry
Research InstitutionTokyo Medical and Dental University

Principal Investigator

KAGAYA Noritaka  Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 助教 (40372437)

Project Period (FY) 2008 – 2009
Keywords口腔癌 / カテキン / アポトーシス / p38 / c-Abl
Research Abstract

In the present study, I examined the mechanism of EGCG (a green tea catechin)-induced apoptosis in human oral cancer cell lines. After EGCG treatment, PARP and caspases were activated accompanied with MAPK p38 activation in ZA cell. A non-receptor tyrosine kinase c-Abl is known to activate MAPK p38 specifically. Therefore, role of c-Abl in EGCG-induced cell apoptosis was examined using c-Abl inhibitor imatinib or c-Abl shRNA. Inhibition of c-Abl signaling effectively suppressed EGCG-induced apoptosis in ZA cell. In addition, nuclear localization of c-Abl was observed after EGCG treatment. In HSC4 cell in which apoptosis was not induced by EGCG, apoptosis was provoked by EGCG after the transfection of c-Abl gene. In conclusion, it was suggested that c-Abl have important roles in EGCG-induced cell apoptosis.

  • Research Products

    (2 results)

All 2009 2008

All Presentation (2 results)

  • [Presentation] 口腔癌細胞において緑茶カテキンが誘導するc-Ablを介するアポトーシスシグナル2009

    • Author(s)
      加賀谷紀貴
    • Organizer
      歯科基礎医学会
    • Place of Presentation
      朱鷺メッセ新潟コンベンションセンター
    • Year and Date
      20090909-20090911
  • [Presentation] ヒト口腔癌細胞に対する緑茶カテキンの細胞死誘導機構2008

    • Author(s)
      加賀谷紀貴、原征彦
    • Organizer
      日本分子生物学会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      20081209-20081212

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Published: 2011-06-18   Modified: 2016-04-21  

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