2009 Fiscal Year Final Research Report
Study of bone and cementum formation through phosphate/pyrophosphate balance
| Project/Area Number |
20791335
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Morphological basic dentistry
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
SATO Sunao Osaka University, 大学院・歯学研究科, 講師 (70335660)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Keywords | 硬組織 / リン酸 / ピロリン酸 / 骨 / セメント質 |
|---|
| Research Abstract |
We revealed that phosphate/pyrophosphate imbalance inhibit the proliferation of cementoblast and osteoblast cell line but enhanced the differentiation of cementoblast and osteoblast cell line with the experiment of additional phosphate mimicking phosphate/pyrophosphate imbalance. Moreover, we revealed that phosphate/pyrophosphate imbalance changes some of the same gene in cementoblast and osteoblast cell line, but some other genes were different between cementoblast cell line and osteoblast cell line.
|
