Identification of a novel tumor suppressor gene at 1p36 chromosomal region in oral squamous cell carcinomas.

2010 Fiscal Year Final Research Report

• Project/Area Number: 20791337
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Morphological basic dentistry
• Research Institution: Okayama University
• Principal Investigator: TAMAMURA Ryo Okayama University, 大学院・医歯薬学総合研究科, 助教 (00403494)
• Project Period (FY): 2008 – 2010
• Keywords: 癌抑制遺伝子 / 扁平上皮癌 / 口腔癌 / LOH解析

Research Abstract

To investigate the presence of tumor suppressor gene (TSG) at 1p36 chromosomal region, I have analyzed loss of heterozygosity (LOH) in oral squamous cell carcinoma (OSCC). As a result of this study three frequently deleted regions that harbor some potential TSG involved in OSCC carcinogenesis were identified. I focused on RIZ gene which existed in the most highest deletion region, and have done genetic analysis. Two polymorphisms of RIZ gene have been found in OSCC.

Research Products

• [Journal Article] Tumor-specific mutation and down-regulation of ING5 detected in oral squamous cell carcinoma. (2010)
  • Author(s): Cengiz B, Gunduz E, Gunduz M, Beder LB, Tamamura R, Bagci C, Yamanaka N, Shimizu K, Nagatsuka H.
  • Journal Title: Int J Cancer. 127(9) Pages: 2088-94
  • Peer Reviewed
• [Journal Article] Frequent allelic loss of Dkk-1 locus (10q11.2) is related with low distant metastasis and better prognosis in head and neck squamous cell carcinomas. (2010)
  • Author(s): Katase N, Gunduz M, Beder LB, Gunduz E, Al Sheikh Ali M, Tamamura R, Yaykasli KO, Yamanaka N, Shimizu K, Nagatsuka H.
  • Journal Title: Cancer Invest. 28(1) Pages: 103-10
  • Peer Reviewed
• [Journal Article] Potential usage of ING family members in cancer diagnostics and molecular therapy. (2009)
  • Author(s): Gunduz M, Demircan K, Gunduz E, Katase N, Tamamura R, Nagatsuka H.
  • Journal Title: Curr Drug Targets. 10(5) Pages: 465-76
  • Peer Reviewed
• [Journal Article] Deletion at Dickkopf (dkk)-3 locus (11p15.2) is related with lower lymph node metastasis and better prognosis in head and neck squamous cell carcinomas. (2008)
  • Author(s): Katase N, Gunduz M, Beder L, Gunduz E, Lefeuvre M, Hatipoglu OF, Borkosky SS, Tamamura R, Tominaga S, Yamanaka N,Shimizu K, Nagai N, Nagatsuka H.
  • Journal Title: Oncol Res. 17(6) Pages: 273-82
  • Peer Reviewed
• [Presentation] Fine deletion analysis of 1p36 region in oral squamous cell carcinomas (2010)
  • Author(s): Ryo Tamamura
  • Organizer: The 6th Asian Science Seminar
  • Place of Presentation: Taiwan
  • Year and Date: 2010-11-20
• [Presentation] Three regions in 1p36 are preferentially deleted in oral squamous cell carcinoma (2010)
  • Author(s): Hidetsugu Tsujigiwa
  • Organizer: 15th International Congress of Ora1 Pathology and Medicine (IAOP)
  • Place of Presentation: Seoul
  • Year and Date: 2010-08-18
• [Presentation] Threeregions are preferentially deleted in 1p36 region in oral squamous cell carcinoma (2009)
  • Author(s): Mathieu Lefeuvre
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 京都
  • Year and Date: 2009-05-03