2009 Fiscal Year Final Research Report
Aurora-A ; Phosphoregulation and its abnormality in Oral Cancer
| Project/Area Number |
20791338
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
KITAJIMA Shojiro Hiroshima University, 大学院・医歯薬学総合研究科, 助教 (00452590)
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| Project Period (FY) |
2008 – 2009
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| Keywords | Aurora-A / PP2A / 口腔癌 / リン酸化 |
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| Research Abstract |
The purpose of this project is to reveal the mechanism of Aurora-A degradation mediated by phosphorylation and the mechanism that causes Aurora-A overexpression. We examined the binding of Aurora-A to PP2A complex and the activity of PP2A in oral cancer cell lines. We further approached the regulation of PP2A mediated by regulatory B subunit and its biological meanings.
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