2009 Fiscal Year Final Research Report
Analysis for Down-regulated Unknown Gene in Odontogenesis
| Project/Area Number |
20791343
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Tokyo Dental College |
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Principal Investigator |
SASAKI Hodaka Tokyo Dental College, 歯学部, 助教 (50433959)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 歯学 / 発生・分化 |
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| Research Abstract |
It was known that important factors involved in odontogenesis in mouse dental papillae disappear between the pre- and post-natal stages of development. We examined unknown genes had down-regulated expression after birth by genome microarray analysis. The number of up-regulated genes showing an over 2-fold change decreased with time. On the other hand, the number of down-regulated genes was highest between pre- and post-natal (3,130 genes). Those were included 1,038 unknown genes, and it was recognized 16 genes, had significant reduction (fold value >10). These result suggest those down-regulated unknown genes were important factors in normal odontogenesis in dental papillae.
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