2009 Fiscal Year Final Research Report
Control of osteoblastic differentiation of periodontal ligament cells via regulation of SUMOylation
| Project/Area Number |
20791348
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
YUKITA Akira Matsumoto Dental University, 歯学部, 助教 (80401214)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 硬組織再生 / SUMO化修飾 / 細胞分化制御 |
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| Research Abstract |
Establishment of efficient differentiation into osteoblast is one of the most important approaches for regenerative therapy for periodontal disease. Conjugation of SUMO (Small ubiquitin-related modifier) is a post translational modification and regulates various biological events. In this study, I revealed that inhibition of SUMOylation (conjugation of SUMO) enhances osteoblastic differentiation via direct activation of BMP signal.
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