2010 Fiscal Year Final Research Report
The establishment of molecular mechanisms of circadian rhythm in oral cancer cells
| Project/Area Number |
20791368
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Hirosaki University |
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Principal Investigator |
SATO Fuyuki Hirosaki University, 大学院・医学研究科, 助教 (60400131)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 口腔癌 / 概日リズム / DEC / アポトーシス |
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| Research Abstract |
It has not been well understood about the significance of the transcription factor DEC expression in oral cancer. We showed that DEC has circadian rhythm in oral cancer cells, and negatively regulates VEGF and cyclinD1 expression. In addition, the protein expression of DEC1 was intensely stained in the tumor regions compared with those in non-tumor regions. These results suggest that DEC1 plays important roles of the tumor development, and would be new molecular target in oral cancer.
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Research Products
(30 results)
