2009 Fiscal Year Final Research Report

Basic research of the development of new pulp capping agent

Research Project

Project/Area Number	20791391
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Conservative dentistry
Research Institution	Health Sciences University of Hokkaido
Principal Investigator	KOIKE Toshiyuki Health Sciences University of Hokkaido, 歯学部 (10458135)
Project Period (FY)	2008 – 2009
Keywords	直接覆髄 / フォスフォフォリン / コラーゲン / 修復象牙質 / 水酸化カルシウム製剤 / 象牙細管 / 石灰化 / 生体親和性
Research Abstract	Phosphophoryn is an important protein in dentin mineralization. It was extracted from pig teeth, and was combined with type 1 collagen as a trial material. This trial material was placed onto the exposed pulp in maxillary first molar of 8 week-old Wistar rats. Rats were sacrificed 1-3 weeks after operation, and teeth were stained with hematoxylin-eosin. In evaluation of reparative dentin formation and pulp inflammation, the stained sections were compared with calcium hydroxide, a common material. The phosphophoryn-collagen complex induced good reparative dentin, and dental pulp inflammation was mild. Therefore, this material was suggested to have a potential as an alternative material of calcium hydroxide.