2009 Fiscal Year Final Research Report
Analysis of periodontal matrix proteins
| Project/Area Number |
20791479
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
IWATA Takanori Tokyo Women's Medical University, 医学部, 講師 (60431946)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 再生歯学 |
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| Research Abstract |
Periodontal tissue, consisting of periodontal ligament, cementum, and alveolar bone, contains cells with stem cell-like properties. In this study, we extracted and transplanted autologous periodontal ligament cells in a canine model, and the advantage of this cytotherapy was revealed. Furthermore, considering an appropriate environment for periodontal ligament cells, we analyzed the matrix proteins expressed by human periodontal ligament cells. Periodontal specific genes were proposed, and expression of some proteins was confirmed by immunohistochemical studies.
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