2009 Fiscal Year Final Research Report
The mechanism of the enhanced sensitivityof anticancer drug andradioactive ray by the cox-2 inhibitor in oral squamous cell carcinoma
| Project/Area Number |
20791489
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
TANIGUCHI Takahiro Tohoku University, 大学院・歯学研究科, 大学院非常勤講師 (40444012)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 臨床腫瘍学 |
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| Research Abstract |
It's noted that expression of cyclooxygenase(COX) is induced in the inflammatory tissue, on the other hand, it is suggested that COX plays a significant role in oncogenesis during recent years, and high expression of COX-2 is induced in a number of the malignant neoplasm. In this study, the COX-2 selective inhibitor had tended to enhance the effect of anticancer drug and radiation against the human oral squamous carcinoma cell line. These results indicate that the COX-2 selective inhibitor may contribute to improving effect of oral cancer therapy.
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