2010 Fiscal Year Final Research Report
Histologic study on the cellular events during distraction osteogenesis using the tissue-engineered osteogenic materials.
| Project/Area Number |
20791507
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Nagoya University |
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Principal Investigator |
KINOSHITA Kazuhiko Nagoya University, 医学部附属病院, 医員 (40467296)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 顎骨延長法 / 骨髄間質細胞 / 組織工学 |
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| Research Abstract |
The rabbits received an injection of cultured bone marrow stromal cells(BMSCs) or BMP-2 into the distracted tissue at the end of distraction. Each distracted mandible and gingival tissue were evaluated at 2, 4, and 6 weeks after the end of distraction.
This study showed that an injection of tissue-engineered osteogenic material at the end of distraction promoted new bone formation following a higher rate of distraction (3.0 mm / day). However, these materials might not affect distracted gingival tissue.
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