2009 Fiscal Year Final Research Report
The Study of Protective Effect of Intravenous and Inhalation Anesthetic to Oxidative Stress in Central Nerve System
| Project/Area Number |
20791513
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
HIGUCHI Hitoshi Okayama University, 岡山大学病院, 助教 (30423320)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 中枢神経 / 酸化ストレス / 麻酔薬 |
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| Research Abstract |
I aimed the establishment of experimental animal model of the oxidative stress in the central nerve system (CNS) to research the protective effect of anesthetics to oxidative stress in CNS. I made the rat Hemorrhage shock model that was initiated by bleeding, kept low blood pressure for 1 hour, and returned to normal blood pressure. After that, I studied whether oxidative stress was present in CNS. In the result, I could detect the expression of Heme Oxygenase-1 that was oxidative stress-specific enzyme in CNS. This means that Hemorrhage shock model is the experimental animal model of the oxidative stress in CNS.
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