2009 Fiscal Year Final Research Report
Fabrication of the scaffold with growth factor release and experimental study of the scaffold for bone regeneration
| Project/Area Number |
20791528
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
TATEHARA Seiko The University of Tokushima, 医学部・歯学部附属病院, 助教 (90380089)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 生体材料 / 再生医療 / セラミック / 細胞・組織 |
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| Research Abstract |
We have fabricated highly interconnecting, macropouros hybrid scaffolds of poly (lactide-co-glycolide)(PLGA) and apatite cement (AC). The aim of this study was to determine the effectiveness of bFGF on bone regeneration within PLGA-AC scaffold. PLGA-AC scaffolds with bFGF (PLAC-F) were implanted into the drill hole defects of 4 mm in diameter were made in the tibiae of rabbits. After 6 weeks, PLAC-F scaffolds were significantly infiltrated with new more bone tissue in the medullary region. These findings demonstrate that PLAC scaffold incorporated with bFGF has a great advantage for bone tissue engineering.
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