2010 Fiscal Year Final Research Report
Study on the role of dendritic cells in oral autoimmune diseases
| Project/Area Number |
20791530
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
KAKEHASHI Hiroe Kyushu University, 病院・顎口腔外科, 医員 (30452775)
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| Co-Investigator(Renkei-kenkyūsha) |
KAWANO Shintaro 九州大学, 病院・顎口腔外科, 助教 (00398067)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 樹状細胞 / 自己免疫疾患 / 扁平苔癬 / シェーグレン症候群 / 白板症 / 扁平上皮癌 / 免疫療法 / 癌幹細胞 |
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| Research Abstract |
For target lead to immunotherapy using dendritic cells, or how to get involved in the occurrence of oral Squamous Cell Carcinoma (OSCC), differentiation and proliferation, recognizing Δ Np63 normal oral mucosa epithelial stem cell markers in the research and study, the research has been conducted. As a result, heavy degree of epithelial dysplasia suggested that from easy-to-cancer by OSCC to Δ Np63 appearance are involved in the occurrence of OSCC are higher degrees as the expression of Δ Np63 higher was also the expression of epithelial dysplasia. In addition, was considered Δ Np63 is involved in OSCC cell differentiation and proliferation.
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