Identification of new factors concerned with anti-cancer drugs resistant using proteome analysis and clinical application of its factors.

2010 Fiscal Year Final Research Report

• Project/Area Number: 20791535
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: Kumamoto University
• Principal Investigator: YOSHITAKE Yoshihiro Kumamoto University, 医学部附属病院, 助教 (00423682)
• Project Period (FY): 2008 – 2010
• Keywords: 癌 / 歯学 / プロテオーム / 蛋白質 / 遺伝子

Research Abstract

In present, we identified novel factors concerned with anti-cancer drug resistance using cDNA microarray analysis. We identified some anti-cancer drug resistant factors, but we can't still report in a paper. In a few days we will write up experimental data in a paper.
In the future, we hope to make target therapy regents to reject oral cancers. We are considering that custom-made vaccine using anti-cancer drugs considering her genetic background is possible.

Research Products

• [Journal Article] Phase II Study of Preoperative Concurrent Chemoradiation Therapy with S-1 in Patients with T4 Oral Squamous Cell Carcinoma. (2010)
  • Author(s): Tomoko Nomura, Ryuji Murakami, Ryo Toya, Keiko Teshima, Aya Nakahara, Toshinori Hirai, Akimitsu Hiraki, Hideki Nakayama, Yoshihiro Yoshitake, Kazutoshi Ota, Takehisa Obayashi, Yasuyuki Yamashita, Natsuo Oya, Masanori Shinohara
  • Journal Title: Int J Radiat Oncol Biol Phys. 76 Pages: 1347-1352
  • Peer Reviewed
• [Journal Article] Haemophilic pseudotumour of the mandible in a 5-year-old patient. (2010)
  • Author(s): Yoshitake Y, Nakayama H, Takamune Y, Yasunaga M, Hiraki A, Shinohara M.
  • Journal Title: Int J Oral Maxillofac Surg 40 Pages: 120-123
  • Peer Reviewed
• [Journal Article] PTCH1遺伝子のミスセンス変異が認められた母斑基底細胞癌症候群の1例 (2010)
  • Author(s): 吉武義泰、中山秀樹、福間大喜、尾木秀直、平木昭光、篠原正徳
  • Journal Title: 日本口腔外科学会誌 56 Pages: 730-734
  • Peer Reviewed
• [Presentation] URLC10とTTKペプチドを用いた癌ワクチン療法-臨床試験について- (2011)
  • Author(s): 吉武義泰
  • Organizer: 日本口腔腫瘍学会
  • Place of Presentation: 熊本崇城大学市民ホール
  • Year and Date: 2011-01-27
• [Presentation] Phase I/II clinical trial of cancer vaccine therapy using A3243 and C7457 peptides for locally advanced, metaatatic, or unresectable oral cancer (2010)
  • Author(s): 中元雅史, 吉武義泰, 中山秀樹, 安永真子, 田中拓也, 永田将士, 福間大喜, 平木昭光, 濱田哲暢, 吉田浩二, 角田卓也, 齊藤秀行, 西村泰治, 中村祐輔, 篠原正徳
  • Organizer: 日本癌治療学会
  • Place of Presentation: 京都 京都国際会議場
  • Year and Date: 2010-10-29
• [Presentation] Phase I/II clinical trial of peptide vaccine therapy for locally advanced, metaatatic, or unresectable oral cancer (2010)
  • Author(s): 吉武義泰, 中山秀樹, 中元雅史, 安永真子, 田中拓也, 永田将士, 福間大喜, 川原健太, 中川純泰, 大田宜彦, 高宗康隆, 尾木秀直, 太田和俊, 平木昭光, 篠原正徳
  • Organizer: 日本口腔外科学会
  • Place of Presentation: 千葉幕張メッセ
  • Year and Date: 2010-10-17
• [Presentation] Phase I/II clinical trial of cancer vaccine therapy using A3243 and C7457 peptides for locally advanced, metaatatic, or unresectable oral cancer (2010)
  • Author(s): 吉武義泰, 中山秀樹, 中元雅史, 安永真子, 福間大喜, 田中拓也, 永田将士, 平木昭光, 濱田哲暢, 齊藤秀行, 吉田浩二, 角田卓也, 中村祐輔, 西村泰治, 篠原正徳
  • Organizer: 日本口腔外科学会
  • Place of Presentation: 熊本 崇城大学市民ホール
  • Year and Date: 2010-07-23