2009 Fiscal Year Final Research Report
Regenerative mechanism by inoculation of neural stem cells on orofacial injury and neuropathic pains.
| Project/Area Number |
20791540
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
KAI Aya Kyushu Dental College, 歯学部, 特別研修員 (80453231)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 炎症 / 癌 / 異常疼痛 / インドメタシン |
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| Research Abstract |
Orofacial cancer rat model exhibits allodynia and hyperalgesia, but it is unclear whether or not the cancer-induced pains are secondarily evoked by cancer-induced inflammation. To address the question, we compared the effects of an anti-inflammatory drug, indomethacin, on abnormal pain in the orofacial inflammation and cancer models. From results, it is suggested that pains in the orofacial cancer model are not significantly mediated by cancer-induced peripheral inflammation although there is a slight involvement.
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