2009 Fiscal Year Final Research Report
The effect of manners of administration and timing of sevoflurane on myocardial ischemia/reperfusion injury.
| Project/Area Number |
20791554
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Kanagawa Dental College |
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Principal Investigator |
FURUYA Munetaka Kanagawa Dental College, 歯学部, 講師 (90318890)
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| Project Period (FY) |
2008 – 2009
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| Keywords | セボフルレン / 心筋虚血再灌流障害 / 8-OHdG・ |
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| Research Abstract |
【2008】We compared 3.9% sevoflurane exposure groups in six different manners of administration with control group. There were no significant differences in duration of arrhythmias during myocardial ischemia and reperfusion and I/R (infarct size /area at risk) among seven groups. Although we measured 8-OHdG・in the blood, we could not detect it.
【2009】We compared continuous sevoflurane exposure groups in four different concentrations (0.5 %, 1.0%, 1.5%, 2.0%) under k/x anesthesia with control group. I/R (infarct size /area at risk) was reduced in a 1.0% sevoflurane exposure group. 1.0% continuous sevoflurane exposure depressed production of 8-OHdG^・.
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