2009 Fiscal Year Final Research Report
Research that clarify the mechanism of cleft palate disease, and aim to development of tissue engineering treatment for palatal tissue.
| Project/Area Number |
20791581
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
OKA Kyoko Nihon University, 歯学部, 助教 (60452778)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 神経堤細胞 / 口蓋裂 / TGF-bシグナル |
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| Research Abstract |
The results of analysis for localization of cranial neural crest cells (CNC) in palatal tissue by using Wnt1-cre ; R26R mice, not only hard palate also soft palate was composed by CNC. During development of soft palate, palatine aponeurosis is organized by CNC cells expressing Col I mRNA. TGF-b signaling controls the proliferation of palatal mesenchymal cells and induces Col I protein deposition.
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