Analysis of regulatory mechanisms of odontoblast differentiationby novel gap junction protein

2009 Fiscal Year Final Research Report

• Project/Area Number: 20791583
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Kyushu University
• Principal Investigator: IWAMOTO Tsutomu Kyushu University, 病院, 助教 (90346916)
• Project Period (FY): 2008 – 2009
• Keywords: 歯胚発生 / 象牙芽細胞 / マトリックス蛋白 / 細胞間蛋白

Research Abstract

To find genes, important for tooth development, we had generated tooth cDNA library, and have been trying to find novel and functional genes. So far, we have identified a novel matrix protein gene, named TM14/Fibluin7. We found that TM14/Fibluin 7 has an important role for odontoblast attachment. And also, we have identified a hard tissue specific novel gap junction gene, and have been analyzing its function in tooth, cartilage and bone development.

Research Products

• [Journal Article] The critical role of heparin binding domains of ameloblastin for dental epithelium cell adhesion and ameloblastoma proliferation. (2009)
  • Author(s): Sonoda A*, Iwamoto T*, Nakamura T, Fukumoto E, Yoshizaki K, Yamada A, Arakaki M, Harada H, Nonaka K, Nakamura S, Yamada Y, Fukumoto S.
  • Journal Title: J Biol Chem 284(40) Pages: 27176-84
  • Peer Reviewed
• [Journal Article] Influences of Interferon-gamma on Cell Proliferation and Interleukin-6 Production in Down Syndrome derived Fibroblasts (2009)
  • Author(s): Iwamoto T, Yamada A, Yuasa K, Fukumoto E, Nakamura T, Fujiwara T, Fukumoto S.
  • Journal Title: Archives of Oral Biology 54(10) Pages: 963-9
  • Peer Reviewed
• [Journal Article] Prevalence of Natal/Neonatal Teeth in Cleft Lip and Palate Infants (2009)
  • Author(s): Iwamoto T, Yoshizaki K, Sonoda A, Nakamura Y, Matsuishi Y, Yamaguchi N, Nonaka K
  • Journal Title: Ped Dent J 19(1) Pages: 46-51
  • Peer Reviewed
• [Journal Article] Dens evaginatus and dens invaginatus in a mandibular central incisor (2009)
  • Author(s): Iwamoto T, Yoshizaki K, Nakamura Y, Sonoda A, Nakamoto Y, Okuma Y, Tamiya R, Nonaka K
  • Journal Title: Ped Dent J 19(1) Pages: 145-149
  • Peer Reviewed
• [Presentation] Mechanisms of ameloblast differentiation by Neurotrophic Factors (2009)
  • Author(s): Ono M, Iwamoto T, Yoshizaki K, Fukumoto S
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2009-12-12
• [Presentation] 下顎第二乳臼歯の埋伏症例における不正咬合について (2009)
  • Author(s): 新垣真紀子、岩本勉、山田亜矢、鈴木宏治、中村卓史、福本敏
  • Organizer: 第27回日本小児歯科学会北日本地方会大会および総会
  • Place of Presentation: 石巻専修大学
  • Year and Date: 2009-10-24
• [Presentation] 象牙芽細胞の分化に関わる新奇ギャップ結合分子の同定 (2009)
  • Author(s): 岩本勉、中村卓史、吉崎恵悟、山田亜矢、山田吉彦、福本敏
  • Organizer: 第51回歯科基礎医学会学術大会ならびに総会
  • Place of Presentation: 朱鷺メッセ新潟コンベンションセンター
  • Year and Date: 2009-09-10
• [Presentation] 新奇細胞間蛋白Pannexin 3による象牙芽細胞の増殖と分化の制御 (2009)
  • Author(s): 岩本勉, 中村卓史, 山田亜矢, 山田吉彦, 福本敏
  • Organizer: 第6回東北大学バイオサイエンスシンポジウム
  • Place of Presentation: 仙台国際センター
  • Year and Date: 2009-06-16
• [Presentation] Platelet-derived growth factors play an important role in early tooth germ development (2009)
  • Author(s): Nan W, Yamamoto S, Iwamoto T, Yoshizaki K, Sonoda A, Yamada A, Nonaka K, Fukumoto S
  • Organizer: 第47回日本小児歯科学会大会
  • Place of Presentation: 大阪大学コンベンションセンター
  • Year and Date: 2009-05-15