2010 Fiscal Year Final Research Report
Analysis of the neural regulation of the bone metabolism under the mechanical stress.
| Project/Area Number |
20791586
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
KUROISHI Kayoko (中尾 加代子) Kyushu Dental College, 歯学科, 助教 (60468303)
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| Project Period (FY) |
2008 – 2010
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| Keywords | メカニカルストレス / 神経 / 歯根膜線維芽細胞 / オステオアクチビン / 骨形成 |
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| Research Abstract |
To analyze the neural regulation of the bone metabolism under the mechanical stress, we investigated the role of osteoactivin (OA) in the human periodontal ligament (HPDL) cells. When the mechanical stress was loaded to the rat molar, OA appeared in the HPDL cells, osteoblasts, and osteoclasts. When HPDL cells were given the tension force, the immunoreactivity of OA was reduced. These results suggested that tension forces induced the release of extracellular domain of OA, resulting in the stimulation of bone formation at the tension side.
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