Effect of cytokine for integration after bone graft in rat with palatal cleft

2010 Fiscal Year Final Research Report

• Project/Area Number: 20791604
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Fukuoka Dental College
• Principal Investigator: HATA Yuichiro Fukuoka Dental College, 歯学部, 助教 (60465747)
• Project Period (FY): 2008 – 2010
• Keywords: BMP / 骨移植 / 創傷治癒 / 口蓋裂 / フィブリン糊

Research Abstract

The purpose of this study is to clarify the effect of BMP and bFGF on integration of bone graft. 40 days Wistar rat was used for the making the rat palatal loss model, and establishment of the quantitative evaluation method of the bone graft. As a result, the rat palatal loss model's making was established. The palatal bone was drilled by a round bar of 1mm in the diameter. For the method of bone graft, the bone deleted in a round bar was gathered, it mixed with a fibrin paste, and it transplanted to the bone loss part.
For the effect of the cytokine of the grafted bone, the results suggested that BMP2 showed an excellent result in the integration and bone growth qualitatively. It will be necessary to examine the establishment of quantification and the effect of bFGF in the future.