2009 Fiscal Year Final Research Report
Functional analysis of amelotin and its application for periodontal regeneration.
| Project/Area Number |
20791607
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Periodontal dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
IWASAKI Kengo Tokyo Medical and Dental University, 医学部, 助教 (40401351)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 再生 / 歯周組織 |
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| Research Abstract |
Mouse amelotin gene was over-expressed in mouse osteoblatsic cell line and osteoblastic differentiation was induced. We observed enhanced mineralized nodule formation, whereas osteoblastic differentiation marker gene expressions were not changed. In immuno-electron microscopic observation, we also found the tendency of amelotin to bind to calcium and phosphate when the cells were stimulated to form mineralized nodule. These data suggested the capacity of amelotin to enhance bone formation and possibility of its application for periodontal regeneration.
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