2009 Fiscal Year Final Research Report
The anti-inflammatory effect of irsogladine maleate in human gingival tissue.
| Project/Area Number |
20791613
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Periodontal dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
FUJITA Tsuyoshi Hiroshima University, 病院, 助教 (80379883)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 歯周病予防 / 歯肉上皮細胞 / マレイン酸イルソグラジン / ケモカイン / 細胞接着因子 |
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| Research Abstract |
By regulating the intercellular junctional complex and chemokine secretion in human gingival epithelial cells (HGEC), irsogladine maleate (IM) may be useful to prevent periodontal disease. To clarify the effects and regulatory mechanism of IM in vivo and in vitro, we examined the expression of E-cadherin and neutrophil chemotaxis induced by A. actinomycetemcomitans under IM pretreatment. In the present study, we demonstrated that IM inhibited the A. actinomycetemcomitans-induced inflammatory response in gingival epithelium by suppressing neutrophil migration in vivo and in vitro. In addition, IM recovered the A. actinomycetemcomitans-induced reduction in E-cadherin, suggesting enhancement of the barrier function of gingival epithelium. In conclusion, IM may control A. actinomycetemcomitans-induced gingival inflammation by regulating neutrophil migration and E-cadherin expression in gingival epithelium.
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