2009 Fiscal Year Final Research Report
The development of drug for alveolar bone regeneration targeting the Wnt signaling pathway
| Project/Area Number |
20791616
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Periodontal dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
MATSUZAKI Etsuko Kyushu University, 大学病院, 助教 (20432924)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 骨芽細胞 / Wntシグナル / 骨芽細胞 / 再生医学 |
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| Research Abstract |
Dkk1 is an inhibitor of Wnt signaling and inhibits bone formation. Recent studies show that anti-Dkk1 antibody is useful for the osteolytic disease including multiple myeloma and rheumatoid arthritis. We found that anti-Dkkl antibody induced osteoblast differentiation and calcification.
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