2009 Fiscal Year Final Research Report
Molecular biological analysis of periodontitis and metabolic syndrome based on renin-angiotenshin system
| Project/Area Number |
20791618
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Periodontal dentistry
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| Research Institution | Kagoshima University |
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Principal Investigator |
NAKAMURA Toshiaki Kagoshima University, 大学院・医歯学総合研究科, 助教 (60381183)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 歯周病 / 歯肉 / メタボリックシンドローム / アンジオテンシン / RAS |
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| Research Abstract |
The aim of the present study was to investigate the expression of renin-angiotensin system (RAS) components, which has been considered to be concerned with several steps of metabolic syndrome, in human gingival tissues and the effects of RAS on inflammatory reactions in cultured human gingival fibroblasts (HGF). This study demonstrated that tissue RAS exists in HGT and IL-6 induced by IL-1β may be partially regulated through AT1R in HGF. These facts suggest that RAS may be involved in the regulation of inflammatory responses in periodontal disease.
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