Effects of obesity on oxidative stress and periodontitis progression

2009 Fiscal Year Final Research Report

• Project/Area Number: 20791642
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Social dentistry
• Research Institution: Okayama University
• Principal Investigator: TOMOFUJI Takaaki Okayama University, 岡山大学病院, 講師 (80335629)
• Project Period (FY): 2008 – 2009
• Keywords: 歯学 / 栄養 / トランスレーショナルリサーチ

Research Abstract

Studies indicate a correlation between obesity and periodontitis. We hypothesized that increased blood oxidative stress following obesity might damage periodontal tissues. The obese Zucker rats (n= 14) and their lean littermates (n= 14) were divided into two groups of 7 rats, respectively. In one of each group, periodontitis was ligature-induced for 4 wks, while the other group was left unligated. Compared to lean Zucker rats, obese Zucker rats showed enhanced gingival 8-hydroxydeoxyguanosine levels, with increasing serum reactive oxygen metabolites. The periodontal lesion in obese rats also showed higher 8-hydroxydeoxyguanosine levels and polymorphonuclear leukocyte infiltration than the inflamed ones in lean rats, with down-regulation of multiple cytochrome P450 gene expression. These findings suggest that obesity induced gingival oxidative damage by increasing blood oxidative stress and augmented periodontal inflammation due to a reduced capacity for xenobiotic detoxification in rats.

Research Products

• [Journal Article] Effects of obesity on gingival oxidative stress in a rat model (2009)
  • Author(s): Tomofuji T, Yamamoto T, Tamaki N, Ekuni D, Azuma T, Sanbe T, Irie K, Kasuyama K, Umakoshi M, Murakami J, Kokeguchi S, Morita M
  • Journal Title: J Periodontol 80 Pages: 1324-1329
  • Peer Reviewed
• [Journal Article] Vitamin C intake attenuates the degree of experimental atherosclerosis induced by periodontitis in the rat by decreasing oxidative stress (2009)
  • Author(s): Ekuni D, Tomofuji T, Sanbe T, Irie K, Azuma T, Maruyama T, Tamaki N, Murakami J, Kokeguchi S, Yamamoto T
  • Journal Title: Arch Oral Biol 54 Pages: 495-502
  • Peer Reviewed
• [Journal Article] Effects of improvement of periodontal inflammation by toothbrushing on serum lipopolysaccharide concentration and liver injury in rats (2009)
  • Author(s): Tomofuji T, Ekuni D, Sanbe T, Azuma T, Tamaki N, Irie K, Maruyama T, Yamamoto T, Watanabe T, Miyauchi M, Takata T
  • Journal Title: Acta Odontol Scand 67 Pages: 200-205
  • Peer Reviewed
• [Journal Article] Periodontitis and increase in circulating oxidative stress (2009)
  • Author(s): Tomofuji T, Irie K, Sanbe T, Ekuni D, Azuma T, Tamaki N, Yamamoto T, Morita M
  • Journal Title: Jap Dent Sci Rev 45 Pages: 46-51
  • Peer Reviewed
• [Journal Article] Periodontitis-induced lipid peroxidation in rat descending aorta is involved in initiation of atherosclerosis (2009)
  • Author(s): Ekuni D, Tomofuji T, Sanbe T, Irie K, Azuma T, Maruyama T, Tamaki N, Murakami J, Kokeguchi S, Yamamoto T
  • Journal Title: J Periodont Res 44 Pages: 434-442
  • Peer Reviewed
• [Journal Article] Vitamin C intake inhibits serum lipid peroxidation and osteoclast differentiation on alveolar bone in rats fed on a high-cholesterol diet (2009)
  • Author(s): Sanbe T, Tomofuji T, Ekuni D, Azuma T, Irie K, Tamaki N, Yamamoto T, Morita M
  • Journal Title: Arch Oral Biol 54 Pages: 235-240
  • Peer Reviewed
• [Presentation] Effect of non-surgical periodontal therapy on plasma reactive oxygen metabolites (2008)
  • Author(s): Tamaki N, Yamanaka R, Ekuni dTomofuji T, Yamamoto T, Morita M
  • Organizer: The 56th Annual Meeting of Japanese Association for Dental Research
  • Place of Presentation: Nagoya
  • Year and Date: 20081129-20081130
• [Presentation] Effects of Obesity on OxidatiStress in Rat Gingiva (2008)
  • Author(s): Tomofuji T, Sanbe T, Tamaki N, Ekuni D, Kasuyama K, Umakoshi M, Irie K, Azuma T, Murakami J, Kokeguchi S, Yamamoto T, Morita M
  • Organizer: The 56th Annual Meeting of Japanese Association for DentalResearch
  • Place of Presentation: Nagoya
  • Year and Date: 20081129-20081130
• [Presentation] 予防歯科学の基礎研究の一例 (2008)
  • Author(s): 友藤孝明
  • Organizer: 第57回日本口腔衛生学会・総会
  • Place of Presentation: 埼玉
  • Year and Date: 20081002-20081004
• [Presentation] 歯周炎モデルラットにおける歯肉酸化ストレス度・抗酸化力に対するビタミンC全身投与の効果 (2008)
  • Author(s): 入江浩一郎, 友藤孝明, 江國大輔, 三部俊博, 東哲司, 丸山貴之, 玉木直文, 山本龍生, 森田学
  • Organizer: 第57回日本口腔衛生学会・総会
  • Place of Presentation: 埼玉
  • Year and Date: 20081002-20081004
• [Presentation] 高コレステロール食によるラットの血清過酸化脂質の増加と歯槽骨における破骨細胞の分化:ビタミンC摂取の影響 (2008)
  • Author(s): 三部俊博, 友藤孝明, 江國大輔, 東哲司
  • Organizer: 第29回岡山歯学会学術大会
  • Place of Presentation: 岡山
  • Year and Date: 2008-11-24
• [Presentation] アンケートによる歯周疾患スクリーニングの有効性 (2008)
  • Author(s): 小山玲子, 玉木直文, 丸山貴之, 友藤孝明, 江國大輔, 山中玲子, 東哲司, 山本龍生, 森田学
  • Organizer: 第29回岡山歯学会学術大会
  • Place of Presentation: 岡山
  • Year and Date: 2008-11-24
• [Presentation] 歯の健康に関する保健指導 (2008)
  • Author(s): 友藤孝明
  • Organizer: 特定検診・保健指導実践者育成研修会
  • Place of Presentation: 岡山
  • Year and Date: 2008-07-30
• [Presentation] 小学生における食習慣と咬合力・咬合接触面積の関係 (2008)
  • Author(s): 古田美智子, 山中玲子, Akhter Rahena, 小山玲子, 友藤孝明, 江國大輔, 玉木直文, 東哲司, 山本龍生, 岸本悦央
  • Organizer: 第19回日本口腔衛生学会近畿・中国・四国地方会総会
  • Place of Presentation: 徳島
  • Year and Date: 2008-06-22
• [Presentation] アンケートによる歯周疾患スクリーニングの有効性 (2008)
  • Author(s): 小山玲子, 玉木直文, 丸山貴之, 友藤孝明, 江國大輔, 山中玲子, 東哲司, 山本龍生
  • Organizer: 第19回日本口腔衛生学会近畿・中国・四国地方会総会
  • Place of Presentation: 徳島
  • Year and Date: 2008-06-22
• [Presentation] 歯周組織の状態と血漿の酸化ストレス度・抗酸化力との関係 (2008)
  • Author(s): 丸山貴之, 玉木直文, 友藤孝明, 江國大輔, 山中玲子, 竹内倫子, 山本龍生
  • Organizer: 第51回日本歯周病学会春季学術大会
  • Place of Presentation: 大宮
  • Year and Date: 2008-04-25
• [Presentation] Relationship between periodontal condition and plasma reactive oxygen metabolites in patients in the maintenance phase of periodontal treatment (2008)
  • Author(s): Irie K, Tamaki N, Maruyama T, Tomofuji T, Ekuni D, Yamanaka R, Takeuchi T, Yamamoto T
  • Organizer: 第1回岡山医療教育国際シンポジウム
  • Place of Presentation: 岡山
  • Year and Date: 2008-02-01