Basic study on elucidating mechanism of neuronal plasticity of chronic pain induced by lower extremity immobilization and on its therapy

2009 Fiscal Year Final Research Report

• Project/Area Number: 20800058
• Research Category: Grant-in-Aid for Young Scientists (Start-up)
• Allocation Type: Single-year Grants
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Aichi Medical University
• Principal Investigator: OHMICHI Yusuke Aichi Medical University, 医学部, 助教 (50506673)
• Project Period (FY): 2008 – 2009
• Keywords: 慢性痛 / 可塑性 / 脊髄 / ミクログリア / アストロサイト / 動物モデル / 不活動 / ギプス固定

Research Abstract

We developed a type of chronic pain model caused by two-week cast-immobilization to reveal the mechanism of chronic pain without clear nerve injuries. In this model a long-lasting and widespread hyperalgesia was shown not only in the immobilized side, but also in the contralateral side and in the tail as well. These behavioral studies suggested the implication of central plasticity, therefore in this study we investigated changes in the immunohistochemistry of spinal glial cells after the cast-immobilization. A temporal and spatial association exists between the pain behaviors and spinal glial cells activation in this cast-immobilization chronic pain model.

Research Products

• [Presentation] ギプス固定除去が誘発する痛覚増強と神経因性炎症-ギプス固定慢性痛症モデルによる検討- (2010)
  • Author(s): 大道裕介, 大道美香, 森本温子, 吉本隆彦, 櫻井博紀, 大石仁, 牛田享宏, 浅本憲, 中野隆, 熊澤孝朗
  • Organizer: 第115回日本解剖学会総会・全国学術集会
  • Place of Presentation: 盛岡
  • Year and Date: 2010-03-30
• [Presentation] ギプス固定慢性痛症モデルラットにおける脊髄グリア細胞活性化の変化 (2009)
  • Author(s): 大道美香, 大道裕介, 大石仁, 櫻井博紀, 吉本隆彦, 森本温子, 橋本辰幸, 江口国博, 山口佳子, 中野隆, 熊澤孝朗
  • Organizer: 第44回日本理学療法学術大会
  • Place of Presentation: 東京
  • Year and Date: 2009-05-29
• [Presentation] ギプス固定慢性痛症モデルラットは交感神経系の異常を伴う (2009)
  • Author(s): 吉本隆彦, 江口国博, 櫻井博紀, 大道裕介, 橋本辰幸, 森本温子, 大道美香, 山口佳子, 熊澤孝朗
  • Organizer: 第44回日本理学療法学術大会
  • Place of Presentation: 東京
  • Year and Date: 2009-05-28
• [Presentation] 筋侵害性モデルラットの若齢処置では慢性痛症を発症しなかった (2009)
  • Author(s): 櫻井博紀, 橋本辰幸, 大道裕介, 吉本隆彦, 森本温子, 大道美香, 江口国博, 山口佳子, 熊澤孝朗
  • Organizer: 第44回日本理学療法学術大会
  • Place of Presentation: 東京
  • Year and Date: 2009-05-28
• [Presentation] ギプス固定慢性痛症モデルラットにおける神経因性炎症の変化 (2009)
  • Author(s): 大道裕介, 大道美香, 大石仁, 櫻井博紀, 吉本隆彦, 森本温子, 橋本辰幸, 江口国博, 山口佳子, 中野隆, 熊澤孝朗
  • Organizer: 第44回日本理学療法学術大会
  • Place of Presentation: 東京
  • Year and Date: 2009-05-28
• [Presentation] 下肢ギプス固定がもたらす慢性的痛み行動に伴う脊髄ミクログリア・アストロサイトの変化 (2009)
  • Author(s): 大道裕介, 大道美香, 大石仁, 櫻井博紀, 吉本隆彦, 森本温子, 橋本辰幸, 江口国博, 山口佳子, 中野隆, 熊澤孝朗
  • Organizer: 第114回日本解剖学会総会・全国学術集会
  • Place of Presentation: 岡山
  • Year and Date: 2009-03-30
• [Presentation] 下肢ギプス固定後に発症する慢性的痛み行動における脊髄グリア細胞の関与 (2008)
  • Author(s): 大道裕介, 大道美香, 大石仁, 櫻井博紀, 吉本隆彦, 森本温子, 橋本辰幸, 江口国博, 牛田享宏, 山口佳子, 熊澤孝朗
  • Organizer: 第23回日本整形外科学会基礎学術集会
  • Place of Presentation: 京都
  • Year and Date: 2008-10-23
• [Presentation] Temporal and spatial changes of spinal glial cells in chronic pain model induced by the cast-immobilization. (2008)
  • Author(s): Ohmichi M, Ohmichi Y, Ohishi H, Sakurai H, Yoshimoto T, Morimoto A, Hashimoto T, Ushida T, Yamaguchi Y, Kumazawa T
  • Organizer: 12th World Congress on Pain
  • Place of Presentation: Glasgow
  • Year and Date: 2008-08-20
• [Presentation] Sympathetic dysfunction in the cast-immobilization chronic pain model. (2008)
  • Author(s): Yoshimoto T, Eguchi K, Sakurai H, Ohmichi Y, Hashimoto T, Morimoto A, Ohmichi M, Yamaguchi Y, Kumazawa T
  • Organizer: 12th World Congress on Pain
  • Place of Presentation: Glasgow
  • Year and Date: 2008-08-18
• [Presentation] Changes in pain behavior associated with the spinal glial activations in the chronic pain model by the plaster-immobilization. (2008)
  • Author(s): Ohmichi Y, Ohmichi M, Ohishi H, Sakurai H, Yoshimoto T, Morimoto A, Hashimoto T, Ushida T, Yamaguchi Y, Kumazawa T
  • Organizer: The 3rd Asian Pain Symposium
  • Place of Presentation: Fukuoka
  • Year and Date: 2008-07-19
• [Presentation] Developmental changes of the chronic pain behaviors in rats induced by myopathic treatment. (2008)
  • Author(s): Sakurai H, Hashimoto T, Ohmichi Y, Yoshimoto T, Morimoto A, Ohmichi M, Eguchi K, Ushida T, Yamaguchi Y, Kumazawa T
  • Organizer: The 3rd Asian Pain Symposium
  • Place of Presentation: Fukuoka
  • Year and Date: 2008-07-19
• [Presentation] 慢性的な痛みを起こす下肢不動化モデルラットにおける自律神経機能の異常 (2008)
  • Author(s): 吉本隆彦, 江口国博, 櫻井博紀, 大道裕介, 橋本辰幸, 大道美香, 森本温子, 山口佳子, 熊澤孝朗
  • Organizer: 第30回日本疼痛学会
  • Place of Presentation: 福岡
  • Year and Date: 2008-07-19