2009 Fiscal Year Final Research Report
Delivery of siRNA to central nervous system viablood-brain barrirer transport : Therapy for prion disease
| Project/Area Number |
20800066
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Fukuoka University |
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Principal Investigator |
WATANABE Takuya Fukuoka University, 薬学部, 助教 (90509647)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 薬学 / 感染症 |
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| Research Abstract |
This study aimed to develop new therapy for prion diease without side effects, using a complex of siRNA and RVG-9R. The siRNA decreased expression of prion mRNA and prion protein of scrapie form (PrP^<Sc>). And siRNA/RVG-9R complex bound to cell. However, treatment of siRNA/RVG-9R complex did not affect PrP^<Sc> level in prion-infected cell culture. Sequence of RVG-9R needs to optimize for knock-down of prion.
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