2009 Fiscal Year Final Research Report
Elucidation of mechanisms for toxicity of the protein aggregation in amyotrophic lateral sclerosis
| Project/Area Number |
20800076
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neuroscience in general
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
INOUE Shinichi The Institute of Physical and Chemical Research, 田中研究ユニット, 研究員 (20466030)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 筋萎縮性側索硬化症 / アミロイド線維 / ミトコンドリア / 脂質 |
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| Research Abstract |
Here we show that mutant human SOD1 proteins formed amyloid fibril, and possessed a seeding ability. Mitochondria-specific lipid inhibit amyloid fibril aggregation, rather than promote it. Furthermore, this study confirmed toxicity of the mutant SOD1 amyloid fibrils.
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