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2009 Fiscal Year Final Research Report

Dielectrophoresis-based cell patterning for cell culture chip

Research Project

  • PDF
Project/Area Number 20860017
Research Category

Grant-in-Aid for Young Scientists (Start-up)

Allocation TypeSingle-year Grants
Research Field Biofunction/Bioprocess
Research InstitutionTohoku University

Principal Investigator

INO Kosuke  Tohoku University, 大学院・環境科学研究科, 助教 (00509739)

Co-Investigator(Renkei-kenkyūsha) MATSUE Tomokazu  東北大学, 大学院・環境科学研究科, 教授 (70173797)
SHIKU Hitoshi  東北大学, 大学院・環境科学研究科, 准教授 (10361164)
Project Period (FY) 2008 – 2009
Keywords誘電泳動 / 細胞パターニング / 細胞チップ / バイオMEMS
Research Abstract

In this study, dielectrophoresis-based cell patterning was developed for cell culture chip. Electrodes were designed and electric field simulations were performed to manipulate bioparticles toward target areas. Based on the simulation results, several kinds of devices were fabricated for the formation of localized and non-uniform electric fields. When an appropriate AC voltage was applied to the electrode, array patterns of microparticles such as polystyrene beads, yeasts and cells were rapidly fabricated on the target substrate with ease. The results suggest that the devices can be widely applied for tissue engineering and drug screening.

  • Research Products

    (11 results)

All 2009 2008 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (7 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Detection of hormone active chemicals using genetically engineered yeast cells and microfluidic devices with interdigitated array electrodes2009

    • Author(s)
      Kosuke Ino, Yusuke Kitagawa, Tsuyoshi Watanabe, Hitoshi Shiku, Masahiro Koide, Tomoaki Itayama, Tomoyuki Yasukawa, Tomokazu Matsue
    • Journal Title

      Electrophoresis Vol.30,No.19

      Pages: 3406-3012

    • Peer Reviewed
  • [Journal Article] Manipulation of microparticles for construction of array patterns by negative dielectrophoresis using multilayered array and grid electrodes2009

    • Author(s)
      Kosuke Ino, Hitoshi Shiku, Fumisato Ozawa, Tomoyuki Yasukawa, Tomokazu Matsue
    • Journal Title

      Biotechnology and bioengineering Vol.104, No.4

      Pages: 709-718

    • Peer Reviewed
  • [Presentation] A microfluidic device with interdigitated array electrodes for detection of hormone active chemicals using genetically-engineered yeast cells2009

    • Author(s)
      Kosuke Ino, Yusuke Kitagawa, Hitoshi Shiku, Masahiro Koide, Yoshiko Horiguchi, Tomoaki Itayama, Tomoyuki Yasukawa, Tomokazu Matsue
    • Organizer
      Micro TAS 2009 (The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences)
    • Place of Presentation
      韓国・Jeju
    • Year and Date
      20091101-20091105
  • [Presentation] 誘電泳動による生体微粒子のドットアレイパターン形成2009

    • Author(s)
      小沢文智, 伊野浩介, 珠玖仁, 末永智一
    • Organizer
      化学教育研究協議会東北大会
    • Place of Presentation
      福島
    • Year and Date
      20090920-20090921
  • [Presentation] Construction of dot arrays of microparticles by negative dielectrophoresis using multilayered electrodes2009

    • Author(s)
      Kosuke Ino, Hitoshi Shiku, Fumisato Ozawa, Tomoyuki Yasukawa, Tomokazu Matsue
    • Organizer
      The 60th Annual Meeting of the International Society of Electrochemistry (ISE)
    • Place of Presentation
      中国・北京
    • Year and Date
      20090816-20090821
  • [Presentation] 誘電泳動を用いた生体微粒子のアレイパターニング2009

    • Author(s)
      伊野浩介, 小沢文智, 安川智之, 珠玖仁, 末永智一
    • Organizer
      電気化学会第76回大会
    • Place of Presentation
      京都
    • Year and Date
      20090329-20090331
  • [Presentation] 細胞アレイ作製に向けた誘電泳動用多層電極の開発2008

    • Author(s)
      伊野浩介, 小沢文智, 安川智之, 珠玖仁, 末永智一
    • Organizer
      第18回化学とマイクロ・ナノシステム研究会
    • Place of Presentation
      京都
    • Year and Date
      20081208-20081209
  • [Presentation] 微小電極を用いた誘電詠動による三次元細胞パターニング法の開発2008

    • Author(s)
      伊野浩介, 小沢文智, 安川智之, 珠玖仁, 末永智一
    • Organizer
      日本生物工学会60回大会
    • Place of Presentation
      仙台
    • Year and Date
      20080827-20080829
  • [Presentation] 生体微粒子のアレイ状パターニングに向けた誘電泳動用多層電極の開発2008

    • Author(s)
      伊野浩介, 小沢文智, 安川智之, 珠玖仁, 末永智一
    • Organizer
      電気化学会東北支部第22回若手の会
    • Place of Presentation
      福島
    • Year and Date
      2008-11-28
  • [Book] lab on a chip 技術で作製した電気化学的デバイスと組み替え酵母を利用した内分泌攪乱物質の検出、化学センサ2008

    • Author(s)
      末永智一, 伊野浩介, 珠玖仁
    • Total Pages
      168-173
  • [Remarks] ホームページ等

    • URL

      http://www.che.tohoku.ac.jp/~bioinfo/

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Published: 2011-06-18   Modified: 2016-04-21  

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