2009 Fiscal Year Final Research Report
Study on novel meiosis specific factors for chromosome segregation
| Project/Area Number |
20870011
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Molecular biology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
ISHIGURO Kei-ichiro The University of Tokyo, 分子細胞生物学研究所, 助教 (30508114)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 減数分裂 / 染色体分配 / 生殖細胞 / 動原体 |
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| Research Abstract |
We have screened meiosis specific centromere factors from mouse germ cells using affinity purification and yeast two hybrid techniques. We identified novel kinetochore/chromosome proteins which are specifically expressed in germ cells. Those factors may play a role in changing kinetochore structure for faithful chromosome segregation in meiosis I where a pair of sister kinetochores are in close proximity for monopolar spindle-microtuble attachment.
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