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2010 Fiscal Year Final Research Report

Molecular mechanisms of transcriptional coactivator which has putative binding activity with methylcytosine during learnin

Research Project

  • PDF
Project/Area Number 20870037
Research Category

Grant-in-Aid for Young Scientists (Start-up)

Allocation TypeSingle-year Grants
Research Field Animal physiology/Animal behavior
Research InstitutionTokushima Bunri University

Principal Investigator

HATAKEYAMA Dai  Tokushima Bunri University, 薬学部・薬学科, 講師 (20514821)

Co-Investigator(Renkei-kenkyūsha) KUZUHARA Takashi  徳島文理大学, 薬学部, 教授 (17370035)
ITO Etsuro  徳島文理大学, 香川薬学部, 教授 (80203131)
Project Period (FY) 2009 – 2010
Keywordsエピジェネティクス / メチル化シトシン / ヒストン / アセチル化
Research Abstract

Although the aim of this study was to investigate the molecular mechanisms of translational coactivators in honeybees, we could not isolate these functional genes. Then, we changed the experimental targets with the RNA polymerases of influenza A virus, which has histone-acetylating activity as well as those of honeybee genes. We succeeded in cloning the target genes and expressing its recombinant proteins, which will be used for analyzing tertiary structure and functions.

  • Research Products

    (12 results)

All 2010 2009 2008 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (6 results) Remarks (1 results)

  • [Journal Article] Glutamate transporters in the central nervous system of a pond snail.2010

    • Author(s)
      Hatakeyama D, Mita K, Kobayashi S, Sadamoto H, Fujito Y, Hiripi L, Elekes K, Ito E.
    • Journal Title

      J Neurosci Res 88

      Pages: 1374-1386

    • Peer Reviewed
  • [Journal Article] Anti-influenza activity of phenethylphenylphthalimide analogs derived from thalidomide2010

    • Author(s)
      Iwai Y, Takahashi H, Hatakeyama D, Motoshima K, Ishikawa M, Sugita K, Hashimoto Y, Harada Y, Itamura S, Odagiri T, Tashiro M, Sei Y, Yamaguchi K, Kuzuhara T.
    • Journal Title

      Bioorg Med Chem

    • Peer Reviewed
  • [Journal Article] Contrary effects of octopamine receptor ligands on behavioral and neuronal changes in locomotion of Lymnaea2010

    • Author(s)
      Miyamae Y, Komuro M, Murata A, Aono K, Nishikata K, Kanazawa A, Fujito Y, Komatsu T, Ito D, Abe T, Nagayama M, Uchida T, Gohara K, Murakami J, Kawai R, Hatakeyama D, Lukowiak K, Ito E.
    • Journal Title

      Biol Bull 218

      Pages: 6-14

    • Peer Reviewed
  • [Journal Article] Green tea catechins inhibit the endonuclease activity of influenza A virus RNA polymerase.2009

    • Author(s)
      Kuzuhara T, Iwai Y, Takahashi H, Hatakeyama D, Echigo N.
    • Journal Title

      PLoS Curr Influenza

    • Peer Reviewed
  • [Journal Article] Immunohistological studies on the distribution of learning-related peptides in the central nervous system of conditioned Lymnaea2008

    • Author(s)
      Nomura Y, Hatakeyama D, Horikoshi T, Sakakibara M.
    • Journal Title

      Acta Biol Hung 59

      Pages: 81-92

    • Peer Reviewed
  • [Presentation] グルタミン酸トランスポーターによるモノアラガイ咀嚼リズム形成の制御2009

    • Author(s)
      畠山大, 箕田康一, 小林卓, 定本久世, 伊藤悦朗
    • Organizer
      第47回日本生物物理学会年会
    • Place of Presentation
      徳島県徳島市
    • Year and Date
      20091030-20091101
  • [Presentation] グルタミン酸トランスポーターによるモノアラガイ咀嚼リズムの調節2009

    • Author(s)
      畠山大, 箕田康一, 小林卓, 定本久世, 伊藤悦朗
    • Organizer
      第34回日本比較内分泌学会大会・日本比較生理生化学会第31回大会合同大会
    • Place of Presentation
      大阪府豊中市
    • Year and Date
      20091022-20091024
  • [Presentation] モノアラガイの咀嚼リズム形成におけるグルタミン酸トランスポーターの役割2009

    • Author(s)
      畠山大, 箕田康一, 小林卓, 定本久世, 伊藤悦朗
    • Organizer
      日本動物学会第80回大会
    • Place of Presentation
      静岡県静岡市
    • Year and Date
      20090917-20090920
  • [Presentation] ミツバチのMAPKプロモーター領域におけるメチル化シトシンの季節変動2008

    • Author(s)
      畠山大, Uli Mueller
    • Organizer
      日本動物学会第79回大会
    • Place of Presentation
      福岡県福岡市
    • Year and Date
      20080905-20080907
  • [Presentation] ミツバチMAPKプロモーター部位でのメチル化レベルの季節変化2008

    • Author(s)
      畠山大, Uli Mueller
    • Organizer
      日本比較生理生化学会第30回大会
    • Place of Presentation
      北海道札幌市
    • Year and Date
      20080719-20080721
  • [Presentation] Characterization of DNA methylation in the promoter regions of MAPK in honeybee genomic DNA.2008

    • Author(s)
      Hatakeyama D, Mueller U.
    • Organizer
      6th FENS Forum of European Neuroscience
    • Place of Presentation
      スイス, ジュネーブ
    • Year and Date
      20080712-20080716
  • [Remarks] 日本比較生理生化学会・第18回吉田奨励賞受賞「生物学的階層性に基づくモノアラガイ長期記憶成立機構の包括的解析」2009年10月

    • URL

      http://p.bunri-u.ac.jp/~seika/index.html

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Published: 2011-06-18   Modified: 2016-04-21  

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