2009 Fiscal Year Final Research Report
Analyses of a novel cell shape determinant in rod-shaped bacterium Escherichia coli.
| Project/Area Number |
20870039
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cell biology
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| Research Institution | National Institute of Genetics |
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Principal Investigator |
SHIOMI Daisuke National Institute of Genetics, 系統生物研究センター, 研究員 (70507532)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 大腸菌 / 形態形成 / 細胞骨格 / 蛍光タンパク質 / 細胞膜 / ペプチドグリカン |
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| Research Abstract |
I identified a novel cytoskeletal membrane protein RodZ which regulates cell shape in rod-shaped bacterium E.coli. Cells lacking rodZ are round. It was suggested that RodZ regulates the cell length. Analyses of suppressor mutants of cells lacking rodZ revealed genetic interactions between RodZ and MreB (actin) or cell division machinery that includes FtsZ (tubulin), suggesting that all three cytoskeletal proteins in E.coli collaborate to determine cell shape.
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