2009 Fiscal Year Final Research Report
Study on biomarkers of cardiovascular risks in diabetic model animals
| Project/Area Number |
20880029
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Azabu University |
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Principal Investigator |
ASAI Fumitoshi Azabu University, 獣医学部, 教授 (00511677)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 糖尿病 / 心血管リスク / バイオマーカー / インスリン抵抗性 |
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| Research Abstract |
Present studies were performed to investigate pathophysiologic features related with diabetes and thrombosis, the main factor of cardiovascular risk, in the WBN/Kob-Lepr(fa) rat, a novel model of type 2 diabetes mellitus. It revealed that WBN/Kob-Lepr(fa) rats share a number of common features with human type 2 diabetic patients including obesity, insulin-resistance, damaged pancreatic β cells and abnormal thrombotic biomarkers. WBN/Kob-Lepr(fa) rats may be useful for diabetic researches.
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