2009 Fiscal Year Final Research Report

Study on biomarkers of cardiovascular risks in diabetic model animals

Research Project

Project/Area Number	20880029
Research Category	Grant-in-Aid for Young Scientists (Start-up)
Allocation Type	Single-year Grants
Research Field	Basic veterinary science/Basic zootechnical science
Research Institution	Azabu University
Principal Investigator	ASAI Fumitoshi Azabu University, 獣医学部, 教授 (00511677)
Project Period (FY)	2008 – 2009
Keywords	糖尿病 / 心血管リスク / バイオマーカー / インスリン抵抗性
Research Abstract	Present studies were performed to investigate pathophysiologic features related with diabetes and thrombosis, the main factor of cardiovascular risk, in the WBN/Kob-Lepr(fa) rat, a novel model of type 2 diabetes mellitus. It revealed that WBN/Kob-Lepr(fa) rats share a number of common features with human type 2 diabetic patients including obesity, insulin-resistance, damaged pancreatic β cells and abnormal thrombotic biomarkers. WBN/Kob-Lepr(fa) rats may be useful for diabetic researches.

(3 results)