2009 Fiscal Year Final Research Report
Role for autophagy in oxidative stress-induced prematuere senescence in zebrafish models
| Project/Area Number |
20880045
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Fisheries chemistry
|
|---|
| Research Institution | Fisheries Research Agency |
|---|
Principal Investigator |
IMAMURA Shintaro Fisheries Research Agency, 中央水産研究所, 研究員 (80510007)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Keywords | 酸化ストレス / 老化 / タンパク質分解 / オートファジー / ゼブラフィッシュ |
|---|
| Research Abstract |
Oxidative stress is important for longevity regulation. Accumulation of oxidized proteins may induce cellular senescence during aging process. Autophagy, bulky protein degradation pathway promoted the degradation of oxidized proteins under oxidative stress condition in fish. Autophagy inhibition was induced premature senescence by oxidative stress. These findings indicate that autophagy is essential to prevent the oxidized proteins and exhibit anti-aging functions in fish models.
|
