2009 Fiscal Year Final Research Report
Development of siRNA delivery system with programmed tumor activation
| Project/Area Number |
20890003
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Medical pharmacy
|
|---|
| Research Institution | Hokkaido University |
|---|
Principal Investigator |
HATAKEYAMA Hiroto Hokkaido University, 大学院・薬学研究院, 特任助教 (70504786)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Keywords | ドラッグデリバリー / siRNA / がん治療 |
|---|
| Research Abstract |
siRNA is considered to be a potential therapeutic tool for cancer. To realize siRNA therapy, brilliant DDS carriers should be essential. Therefore, we developed efficient carriers by controlling intracellular trafficking of carriers and release of siRNA in cytosol. Fusogenic peptide accelerated the endosomal escape of the carrier, resulting in enhanced gene knockdown in vitro and in vivo. The superior polycation which exhibited higher activity than the conventional was successfully discovered through screening.
|
