2009 Fiscal Year Final Research Report
Study on the mechanism of the ability of interspecies transmission of avian influenza virus to humans
| Project/Area Number |
20890006
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Virology
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| Research Institution | Hokkaido University |
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Principal Investigator |
OKAMATSU Masatoshi Hokkaido University, 大学院・獣医学研究科, 助教 (00507163)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 鳥インフルエンザウイルス / レセプター特異性 / 宿主 / 伝播 / シアル酸 |
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| Research Abstract |
We studied the distribution of sialic acid receptors of influenza virus in chicken and duck organs by means of lectin histochemistry. Human (Sia alpha2-6Gal) and avian virus receptors (Sia alpha2-3Gal) were identified with Sambucus Nigra (SNA) and Maackia amurensis (MAA) lectins respectively. By lectin histochemistry we found moderate to abundant expression of the human-like virus receptors in the organs as well as binding of the lectins that identify avian-like receptors. In human cells, alpha2-3 sialyltransferase (ST3) was expressed but not the avian virus receptor was existed. It is suggested that enzyme activity of ST3 was regulated in human respiratory epithelial cells.
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