The study of molecular genetics for oral genetic disorder and clinical application about human enamel matrix

2009 Fiscal Year Final Research Report

• Project/Area Number: 20890009
• Research Category: Grant-in-Aid for Young Scientists (Start-up)
• Allocation Type: Single-year Grants
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Hokkaido University
• Principal Investigator: KIDA Miyuki Hokkaido University, 大学院・医学研究科, 客員研究員 (80507442)
• Project Period (FY): 2008 – 2009
• Keywords: 口腔遺伝性疾患 / 遺伝性エナメル質形成不全症 / 遺伝性象牙質形成不全症 / 遺伝子解析 / ヒトエナメルマトリックス蛋白

Research Abstract

I tried to detect responsible genes about oral hereditary diseases, in particular, amelogenesis imperfecta, dentinogenesis imperfecta and oligodontia. I detected de novo mutations of DGI and Oligodontia. These mutations were reported as first cases in Japan. And I tried to apply synthesized human amelogenin protein for new clinical technology.

Research Products

• [Journal Article] De novo mutation in the DSPP gene associated with dentinogenesis imperfecta type II in a Japanese family (2009)
  • Author(s): Miyuki Kida, Tomonori Tsutsumi, Masanobu Shindoh, H Ikeda, Tadashi Ariga
  • Journal Title: European journal of Oral Science 117 Pages: 691-694
  • Peer Reviewed
• [Journal Article] The first confirmed case with C3 deficiency caused by compound heterozygous mutations in the C3 gene; a new aspect of pathogenesis for C3 deficiency (2008)
  • Author(s): Miyuki Kida, Hirotaka Fujioka, Yoshiyuki Kosaka, Kouhei Hayashi, Yukio Sakiyama, Tadashi Ariga.
  • Journal Title: Blood Cells, Molecules and Diseases 40 Pages: 410-413
  • Peer Reviewed