2009 Fiscal Year Final Research Report
Physiological function analysis of stress sensor Keap1
| Project/Area Number |
20890013
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
General medical chemistry
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| Research Institution | Tohoku University |
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Principal Investigator |
SUZUKI Takafumi Tohoku University, 大学院・医学系研究科, 助教 (70508308)
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| Project Period (FY) |
2008 – 2009
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| Keywords | ストレス / 転写因子 / Keap1 / Nrf2 |
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| Research Abstract |
In this study, we investigated the physiological function of stress sensor Keap1 by mouse genetics. We have found that partial repression of Keap1 leads to activation of transcriptional factor Nrf2, resulting in up-regulation of detoxifying enzymes and anti-oxidant proteins, which is effective for cytoprotection. We have further found that functional Keap1 homodimer is essential for Nrf2 repression, which is disrupted by stress stimuli.
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