2009 Fiscal Year Final Research Report
elucidation of the molecular mechanism of angiogenesis induced by the external shockwaves and its therapeutic application for the treatment of chronic heart failure
| Project/Area Number |
20890016
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
NAKANO Matkoto Tohoku University, 大学院・医学系研究科, 助教 (30513551)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 体外衝撃波治療法 / 血管新生 / 慢性心不全 / 血管内皮前駆細胞 |
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| Research Abstract |
We demonstrated that shockwave treatment applied to cultured human umbilical vein endothelial cells upregulated mRNA expression of vascular endothelial growth factor, although further studies are required to determine the optimal condition of the shockwave treatment. Extracorporeal shockwave therapy to a rat model of chronic heart failure was performed, which induced a tendency to improve both left ventricular contractile function and survival rate.
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