2009 Fiscal Year Final Research Report
Analysis of nano-drug delivery system in tumor with low vascular permeability with permeability-enhancing agents.
| Project/Area Number |
20890018
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
General surgery
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| Research Institution | Tohoku University |
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Principal Investigator |
KAWAI Masaaki Tohoku University, 大学院・医学系研究科, 助教 (80513530)
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| Project Period (FY) |
2008 – 2009
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| Keywords | DDS / 新生血管 / EPR効果 / 量子ドット / 血管内皮細胞増殖因子 |
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| Research Abstract |
We clarified appropriate sizes of nanoparticles to use enhanced permeability and retention effects by the single molecular imaging method in vivo. The dynamics of the particles depends on the place in the tumor. We made vascular endothelial growth factor (VEGF)-quantum dot (Qdot) complex. VEGF-Qdot complex attaches vascular endothelial growth factor receptor (VEGFR) expressing tumor cell in vitro higher than platlet-derived growth factor (PDGF)-Qdot and Qdot only. We confirmed reduced blood flow of the mouse ischemic limb model we made by the laser Doppler apparatus.
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Research Products
(15 results)
