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2009 Fiscal Year Final Research Report

Mechanisms of mechanical response in bony tissues derived from CCN2 deficient mice.

Research Project

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Project/Area Number 20890024
Research Category

Grant-in-Aid for Young Scientists (Start-up)

Allocation TypeSingle-year Grants
Research Field Orthodontic/Pediatric dentistry
Research InstitutionTohoku University

Principal Investigator

KAWAKI Harumi  Tohoku University, 大学院・歯学研究科, 助教 (70513670)

Project Period (FY) 2008 – 2009
KeywordsCCNファミリー / CTGF / ノックアウトマウス / 骨芽細胞 / 骨細胞 / 軟骨細胞 / メカニカルストレス / 骨リモデリング
Research Abstract

(1) The lack of CCN2 caused up-regulation of CCN3 in CCN2-null mice, which resulted in the observed phenotypes, such as the resultant delay of terminal differentiation. The involvement of the PTHrP-Ihh loop in the regulation of CCN3 expression is also suggested. (Kawaki et al., JBMR 2008.)
(2) We investigated the expression of CCN family members and their functions osteoblast differentiation. Results showed that CCN members were differentially expressed and therefore could participate in osteoblast lineage progression. (manuscript in preparation.)
(3) We found that the stability of human ccn4 mRNA was regulated by its 3'UTR region. (manuscript in preparation.)

  • Research Products

    (16 results)

All 2010 2009 2008

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (7 results)

  • [Journal Article] Design and utility of CCN2 anchor peptide aptamers2010

    • Author(s)
      Kawaki H, Kubota S, Aoyama E, Fujita N, Hanagata H, Miyauchi A, Nakai K, Takigawa M.
    • Journal Title

      Biochimie (印刷中)

    • Peer Reviewed
  • [Journal Article] Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin suggests abnormal palate development after palatal fusion2010

    • Author(s)
      Imura H, Yamada T, Mishima K, Fujiwara K, Kawaki H, Hirata A, Sogawa N, Ueno T, Sugahara T.
    • Journal Title

      Congenit Anom (Kyoto) (印刷中)

    • Peer Reviewed
  • [Journal Article] Thrombopoietic-mesenchymal interaction that may facilitate both endochondral ossification and platelet maturation via CCN22009

    • Author(s)
      Sumiyoshi K, Kubota S, Furuta RA, Yasui K, Aoyama E, Kawaki H, Kawata K, Ohgawara T, Yamashiro T, Takigawa M.
    • Journal Title

      J Cell Commun Signal. (印刷中)

    • Peer Reviewed
  • [Journal Article] Regulation of chondrocytic phenotype by micro RNA 18a : involvement of Ccn2/Ctgf as a major target gene2009

    • Author(s)
      Ohgawara T, Kubota S, Kawaki H, Kondo S, Eguchi T, Kurio N, Aoyama E, Sasaki A, Takigawa M.
    • Journal Title

      FEBS Lett. 583巻

      Pages: 1006-1010

    • Peer Reviewed
  • [Journal Article] Promotion of bone regeneration by CCN2 incorporated into gelatin hydrogel2008

    • Author(s)
      Kikuchi T, Kubota S, Asaumi K, Kawaki H, Nishida T, Kawata K, Mitani S, Tabata Y, Ozaki T, Takigawa M.
    • Journal Title

      Tissue Eng Part A. 14巻

      Pages: 1089-1098

    • Peer Reviewed
  • [Journal Article] Increased expression of matrilin-3 not only in osteoarthritic articular cartilage but also in cartilage-forming tumors, and down-regulation of SOX9 via epidermal growth factor domain 1-dependent signaling2008

    • Author(s)
      Vincourt JB, Vignaud JM, Lionneton F, Sirveaux F, Kawaki H, Marchal S, Lomazzi S, Plenat F, Guillemin F, Netter P, Takigawa M, Mainard D, Magdalou J.
    • Journal Title

      Arthritis Rheum. 58巻

      Pages: 2798-2808

    • Peer Reviewed
  • [Journal Article] Posttranscriptional regulation of chicken ccn2 gene expression by nucleophosmin/B23 during chondrocyte differentiation2008

    • Author(s)
      Mukudai Y, Kubota S, Kawaki H, Kondo S, Eguchi T, Sumiyoshi K, Ohgawara T, Shimo T, Takigawa M.
    • Journal Title

      Mol Cell Biol. 28巻

      Pages: 6134-6147

    • Peer Reviewed
  • [Journal Article] Cooperative regulation of chondrocyte differentiation by CCN2 and CCN3 shown by a comprehensive analysis of the CCN family proteins in cartilage2008

    • Author(s)
      Kawaki H, Kubota S, Suzuki A, Lazar N, Yamada T, Matsumura T, Ohgawara T, Maeda T, Perbal B, Lyons KM, Takigawa M.
    • Journal Title

      J Bone Miner Res. 23巻

      Pages: 1751-1764

    • Peer Reviewed
  • [Journal Article] Promotion of hydroxyapatite-associated, stem cell-based bone regeneration by CCN22008

    • Author(s)
      Ono M, Kubota S, Fujisawa T, Sonoyama W, Kawaki H, Akiyama K, Shimono K, Oshima M, Nishida T, Yoshida Y, Suzuki K, Takigawa M, Kuboki T.
    • Journal Title

      Cell Transplant 17巻

      Pages: 231-240

    • Peer Reviewed
  • [Presentation] 骨組織形成に関与するCCN4/WISP1遺伝子の発現調節機構の解析2009

    • Author(s)
      川木晴美, 鈴木誠, 藤井俊哉, 青沼智, 久保田聡, 滝川正春, 山本照子
    • Organizer
      第68回 日本矯正歯科学会大会
    • Place of Presentation
      福岡
    • Year and Date
      2009-11-18
  • [Presentation] 骨組織形成に関与するCCN4/WISP1遺伝子の発現調節機構の解析2009

    • Author(s)
      川木晴美, 鈴木誠, 藤井俊哉, 青沼智, 滝川正春, 山本照子
    • Organizer
      第6回 東北大学バイオサイエンスシンポジウム および 第14回 学際ライフサイエンスシンポジウム
    • Place of Presentation
      仙台
    • Year and Date
      2009-06-16
  • [Presentation] Posiible role of CCN family proteins during osteoblast differentiation2009

    • Author(s)
      Kawaki H, Suzuki M, Fujii T, Takigawa M, Takano-Yamamoto T.
    • Organizer
      Tohoku-Forsyth Symposium
    • Place of Presentation
      ボストン、USA
    • Year and Date
      2009-03-10
  • [Presentation] Posiible role of CCN family proteins during osteoblast differentiation2009

    • Author(s)
      Kawaki H, Suzuki M, Fujii T, Takigawa M, Takano-Yamamoto T.
    • Organizer
      3^<rd> International Symposium for Interface Oral Health Science
    • Place of Presentation
      仙台
    • Year and Date
      2009-01-16
  • [Presentation] CCN2欠損マウスを用いた、CCN2およびCCN3によるPTHrP-Ihhループを介した軟骨細胞分化制御機構の解析2008

    • Author(s)
      川木晴美, 久保田聡, 鈴木晶子, 前田健康, 山本照子, 滝川正春
    • Organizer
      第26回 日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2008-10-29
  • [Presentation] CCN2ノックアウトマウスを用いた骨芽細胞分化におけるCCNタンパク質の機能解析2008

    • Author(s)
      川木晴美, 鈴木誠, 藤井俊哉, 久保田聡, 滝川正春, 山本照子
    • Organizer
      第67回 日本矯正歯科学会大会
    • Place of Presentation
      幕張
    • Year and Date
      2008-09-18
  • [Presentation] マウス膜性骨化におけるCCNファミリーメンバーの役割解析2008

    • Author(s)
      川木晴美, 久保田聡, 鈴木晶子, 前田健康, 山本照子, 滝川正春
    • Organizer
      第2回 日本CCNファミリー研究会
    • Place of Presentation
      岡山
    • Year and Date
      2008-08-30

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Published: 2011-06-18   Modified: 2016-04-21  

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