2009 Fiscal Year Final Research Report
The role of inhibitory receptor MAIR-I in innate immunity
| Project/Area Number |
20890027
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
ODA Chigusa University of Tsukuba, 大学院・人間総合科学研究科, 研究員 (50510054)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 炎症 / 敗血症 / MAIR-I / 抑制性レセプター / 自然免疫 |
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| Research Abstract |
Myeloid-associated immunoglobulin-like receptor (MAIR)-I is expressed on most myeloid lineage cells and regulates the activation of these cells. Here we showed that decreased mortality in MAIR-I-deficient mice with experimental peritonitis-sepsis. Because sepsis is the systemic inflammatory syndrome induced by severe infections, remains a leading cause of death worldwide, these results suggest that MAIR-I is a novel molecular target for the treatment of sepsis.
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