Role of DNAM-1 (CD226) in rapid progressive glomerulonephritis

2009 Fiscal Year Final Research Report

• Project/Area Number: 20890030
• Research Category: Grant-in-Aid for Young Scientists (Start-up)
• Allocation Type: Single-year Grants
• Research Field: Kidney internal medicine
• Research Institution: University of Tsukuba
• Principal Investigator: KAI Hirayasu University of Tsukuba, 大学院・人間総合科学研究科, 講師 (60510138)
• Project Period (FY): 2008 – 2009
• Keywords: 急速進行性糸球体腎炎 / DNAM-1(CD226) / 抗糸球体基底膜抗体型糸球体腎炎

Research Abstract

DNAM-1 (CD226) is an adhesion molecule expressed on the majority of NK cells, T cells, monocytes and platelets and physically and functionally associates with leukocyte function-associated antigen-1 (LFA-1). The poliovirus receptor (PVR) CD155 and its family member CD112 (PVR-related family-2 (PRR-2), also called as nectin-2) are ligands for human and mouse DNAM-1. We analyzed rapid progressive glomerulonephritis for wild type mouse and DNAM-1 (CD226) gene deficit mouse using antiglomerulus basement membrane antibody. We compared wild type mouse with the DNAM-1 gene deficit mouse, and the degree of the nephritis was showed weakly. The possibility that DNAM-1 related with the onset of the rapid progressive glomerulonephritis was suggested.