2009 Fiscal Year Final Research Report
The immunoregulation of Notch signaling in graft versus host disease.
| Project/Area Number |
20890031
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hematology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
NISHIKII Hidekazu University of Tsukuba, 附属病院, 病院講師 (30512834)
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| Project Period (FY) |
2008 – 2009
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| Keywords | Notchシグナル / 移植片対宿主病 |
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| Research Abstract |
To clalify how Notch signal works on the immunoregulation system in the graft versus host disease (GVHD), we established the mouse-GVHD model using bone marrow transplant. We also established the purification system of hematopoietic progenitor cells derived from bone marrow and T cells derived from spleen using FACS sorting and MACS. Then, we modified T cell signaling by high-titered retrovirus system.
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