2009 Fiscal Year Final Research Report
Role of mitochondrial ATP-sensitive K^+ channel in postconditioning
| Project/Area Number |
20890037
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
General pharmacology
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| Research Institution | Chiba University |
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Principal Investigator |
NISHIDA Hirofumi Chiba University, 大学院・医学研究院・薬理学, 助教 (80513043)
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| Project Period (FY) |
2008 – 2009
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| Keywords | ミトコンドリア / ATP感受性K^+チャネル / ポストコンディショニング / PI3キナーゼ / グレリン |
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| Research Abstract |
Mitochondrial ATP-sensitive K^+ (mitoK_<ATP>) channel in cardiac myocytes and phosphatidylinositol 3-kinase (PI3K) which is one of the pro-survival kinases play key roles in cardioprotection. This study clarified that PI3K is not linked to mitoK_<ATP> channels although ghrelin treatment at reperfusion reduces infarct size via both mitoK_<ATP> channel activation and a PI3K-mediated pathway.
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